It is common knowledge that serotonin reuptake inhibitors (SSRIs), or the majority of antidepressants, either completely neutralize or drastically reduce the effects of MDMA. Numerous individuals have confirmed this, both in practice (including myself) and from a scientific perspective, and it has a very simple explanation.
Briefly. There are two neurons, which resemble wires except for the synapse (cleft) that separates them. You already know that no current will pass through the hole. Serotonin is the particular neurotransmitter that flies out into the gap, hits the subsequent neuron, and causes the current to flow. Our nervous system functions in this manner.
But there is such a thing as a serotonin transporter (SERT), and in this case, we are only referring to serotonin neurons. Serotonin is absorbed back into the first neuron while some of it travels to the following neuron, burns out, and transmits the signal. Therefore, antidepressants, particularly those in the SSRI class, inhibit (block) this SERT, preventing serotonin from flying back and forcing it to hit the next neuron instead. As the number of impulse transmissions increases, the person becomes satisfied, sociable, and calm.
How does MDMA work?
As a releaser, that is, a substance that causes serotonin to be released. MDMA enters a neuron, grabs serotonin, pulls it out into the synapse, serotonin hits and transmits a signal, MDMA flies back into the first neuron via SERT, grabs serotonin again, pulls it out, there is a signal, MDMA flies back. In a circle, continue like this. This occurs over a period of several hours. Many of you are probably aware of, or have witnessed, what a person goes through. Like the effect of MDMA, serotonin stores deplete and begin to degrade.
From the foregoing, it is easy to conclude that when SERT is inhibited by an antidepressant, MDMA will not enter the neuron, will not release serotonin, and will have no effect. That is, serotonin syndrome, about which people in the West frequently speak (and about which pseudo-experts from Khidra frequently speak), is impossible. If the antidepressants are of the MAOI class, then yes, the possibility of painfully gluing the fins together exists, but that's another story.
I recall a young man telling me in a chat that his girlfriend drinks Zoloft (sertraline), throws MDMA, and everything is fine with her. It was a long time ago, and I wasn't concerned with the pharmacodynamics of MDMA at the time. As you can see, the point here is not my personal experience; the point is that things work one way and only one way.
What is the logical conclusion? Or, in the case of a classic damaged phone, everything was different in reality; for example, a girl had not consumed Zoloft for a month. The second, and more common and tragic, option is that many people consume the substance (especially donuts) without realizing they are being sold something completely different than what was intended.
Mephedrone, by the way, is quite a rush even when taking antidepressants, just as stimulation from amphetamine or meth does not go away.
So, if you're interested in chemical attractions, it's in your best interest to understand how and why your perception changes. Beginning with the mundane care of your health and ending with not allowing cunning degenerates to deceive you.
And all of this neurobiology seems so complex and incomprehensible in words. It is not difficult to comprehend at the level required for an average user.